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Thinness--not obesity--has a genetic component.

P R Costanzo1, S S Schiffman

  • 1Department of Psychology, Duke University, Durham, NC 27706.

Neuroscience and Biobehavioral Reviews
|January 1, 1989
PubMed
Summary
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Genetic factors for body mass are minimal, primarily influencing thinness, not obesity. Inherited thinness may offer some protection against environmental factors contributing to obesity.

Area of Science:

  • Human genetics
  • Obesity research
  • Behavioral science

Background:

  • Understanding the genetic and environmental contributions to body mass is crucial for public health.
  • Previous studies suggest a complex interplay of factors influencing obesity.
  • Adoption studies provide a unique model to disentangle genetic and environmental influences.

Purpose of the Study:

  • To investigate the heritability of body mass in adoptees.
  • To determine if genetic factors influence thinness or obesity.
  • To assess the potential protective effect of inherited thinness against obesity.

Main Methods:

  • Utilized data from the Danish Adoption Register.
  • Compared body mass of adoptees with their biologic and adoptive parents.

Related Experiment Videos

  • Employed Chi-square analyses to assess heritability.

    • Main Results:

    • Biologic heritability for body mass was found to be small.
    • Genetic influence was primarily observed for thin body mass, not obese body mass.
    • No significant genetic heritability was found for obesity.

    Conclusions:

    • Genetic predisposition to obesity appears minimal.
    • Inherited thinness may act as a mild protective factor against obesity development.
    • Environmental factors likely play a more significant role in obesity than previously thought.