Related Experiment Video For extrathyroidal extension
Updated: Mar 28, 2026
Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
Preliminary study of optical coherence tomography imaging to identify microscopic extrathyroidal extension in
Hyoung Shin Lee1,2, Sung Won Shin3, Jung Kweon Bae3
1Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine, Busan, South Korea.
Background And Objectives:
We evaluated the feasibility of using optical coherence tomography (OCT), to identify microscopic extrathyroidal extension (mETE) in ex vivo thyroidectomy specimens of patients who underwent thyroidectomy for the treatment of papillary thyroid carcinoma (PTC).
Methods:
A total of 170 ex vivo OCT images of the tumor, were acquired just after completion of thyroidectomy in 17 patients. The OCT images of each patient were separately evaluated by two blinded investigators, and the outcomes were compared with the histopathology reports.
Results:
The sensitivity and specificity of mETE identification from the OCT images were 81.4% and 86.0%, respectively, for the first investigator, and 82.9% and 87.0%, respectively, for the second investigator. Substantial agreement between the investigators was verified by Cohen's κ (Cohen's κ = 0.772).
Conclusion:
In this preliminary study of a limited series of ex vivo thyroidectomy specimens, we verified the feasibility of OCT as a method of identifying mETE in patients with PTC.
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