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Published on: June 2, 2015
Venous thromboembolism in Croatia - Croatian Cooperative Group for Hematologic Diseases (CROHEM) study
Dražen Pulanić1, Velka Gverić-Krečak, Zlatka Nemet-Lojan
1Dražen Pulanić, Kišpatićeva 12, 10000 Zagreb, Croatia, dpulanic@yahoo.com.
Insights
The incidence of venous thromboembolism (VTE) in Croatia was estimated at 1.185 per 1000 people. Improved thromboprophylaxis for secondary VTE could significantly reduce its burden.
Area of Science:
- Hematology
- Epidemiology
- Public Health
Background:
- Venous thromboembolism (VTE) is a significant global health concern.
- Understanding VTE incidence and characteristics is crucial for public health strategies.
- Previous data on VTE in Croatia is limited.
Purpose of the Study:
- To determine the incidence and characteristics of VTE in Croatia.
- To compare VTE patient demographics and risk factors with international studies.
- To identify potential areas for improving VTE prevention and management.
Main Methods:
- An observational, non-interventional study was conducted in 2011.
- Medical records of newly diagnosed VTE patients from four Croatian counties were reviewed.
- The study population represented 13.1% of the Croatian population.
Main Results:
- 663 VTE cases were identified: 61.5% deep vein thrombosis, 33% pulmonary embolism.
- The median age was 71 years, with 56.3% female patients.
- Secondary VTE (57.3%) was often linked to cancer (40.8%) or immobility (38.2%).
- The estimated VTE incidence was 1.185 per 1000 people.
- 10.6% of patients died, with VTE as the primary cause in 50% of these deaths.
Conclusions:
- VTE characteristics in Croatia align with international findings.
- Enhanced thromboprophylaxis in patients with risk factors for secondary VTE is recommended.
- Implementing improved preventive measures could substantially decrease the VTE burden in Croatia.
Aim:
To analyze the incidence and characteristics of venous thromboembolism (VTE) in Croatia.
Methods:
The Croatian Cooperative Group for Hematologic Diseases conducted an observational non-interventional study in 2011. Medical records of patients with newly diagnosed VTE hospitalized in general hospitals in 4 Croatian counties (Šibenik-Knin, Koprivnica-Križevci, Brod-Posavina, and Varaždin County) were reviewed. According to 2011 Census, the population of these counties comprises 13.1% of the Croatian population.
Results:
There were 663 patients with VTE; 408 (61.54%) had deep vein thrombosis, 219 (33.03%) had pulmonary embolism, and 36 (5.43%) had both conditions. Median age was 71 years, 290 (43.7%) were men and 373 (56.3%) women. Secondary VTE was found in 57.3% of participants, idiopathic VTE in 42.7%, and recurrent VTE in 11.9%. There were no differences between patients with secondary VTE and patients with idiopathic VTE in disease recurrence and sex. The most frequent causes of secondary VTE were cancer (40.8%), and trauma, surgery, and immobilization (38.2%), while 42.9% patients with secondary VTE had ≥2 causes. There were 8.9% patients ≤45 years; 3.3% with idiopathic or recurrent VTE. Seventy patients (10.6%) died, more of whom had secondary (81.4%) than idiopathic (18.6%) VTE (P<0.001), and in 50.0% VTE was the main cause of death. Estimated incidence of VTE in Croatia was 1.185 per 1000 people.
Conclusion:
Characteristics of VTE in Croatia are similar to those reported in large international studies. Improved thromboprophylaxis during the presence of risk factors for secondary VTE might substantially lower the VTE burden.
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