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Regulation of mismatch repair by histone code and posttranslational modifications in eukaryotic cells

Feng Li1, Janice Ortega2, Liya Gu2

  • 1Department of Medical Genetics, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.

DNA Repair
|January 1, 2016
PubMed

Insights

DNA mismatch repair (MMR) maintains genome stability by fixing replication errors and regulating cell cycle checkpoints. This review explores how chromatin structure and epigenetic factors influence MMR processes in eukaryotic cells.

Area of Science:

  • Molecular Biology
  • Genetics
  • Epigenetics

Background:

  • DNA mismatch repair (MMR) is crucial for maintaining genome integrity.
  • Defects in MMR are linked to cancer development.
  • Understanding MMR regulation within chromatin is essential.

Purpose of the Study:

  • To review advancements in understanding MMR within the context of chromatin.
  • To explore the influence of chromatin organization, epigenetics, and protein modifications on MMR.

Main Methods:

  • Literature review of current research on DNA mismatch repair.
  • Analysis of studies investigating chromatin's role in MMR.
  • Examination of epigenetic and posttranslational modification impacts on MMR proteins.

Main Results:

  • MMR efficiency is significantly affected by chromatin structure and compaction.
  • Epigenetic mechanisms, such as DNA methylation and histone modifications, regulate MMR.
  • Posttranslational modifications of MMR proteins fine-tune their activity and localization.

Conclusions:

  • Chromatin context, epigenetic modifications, and protein dynamics are key regulators of MMR.
  • A comprehensive understanding of these factors is vital for cancer research and therapeutic strategies.
Keywords:
DeacetylaseH3K36me3Histone methylationMSH2PCNAPhosphorylationUbiquitination

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