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Comparing the Structure-Function Relationship at the Macula With Standard Automated Perimetry and Microperimetry
Harsha L Rao1, Manideepak Januwada2, Raza S M Hussain2
1VST Glaucoma Center L V Prasad Eye Institute, Banjara Hills, Hyderabad, India 2Narayana Nethralaya, Rajajinagar, Bangalore, India.
Investigative Ophthalmology & Visual Science
|January 1, 2016
Summary
Standard automated perimetry (SAP) and microperimetry (MP) show similar structure-function relationships with ganglion cell-inner plexiform layer (GCIPL) thickness in glaucoma patients. Both methods effectively correlate with SDOCT GCIPL measurements at the macula.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Retinal Imaging
Background:
- Glaucoma diagnosis and monitoring rely on assessing both structural damage and functional vision loss.
- Spectral-domain optical coherence tomography (SDOCT) provides precise measurements of retinal nerve fiber layer and ganglion cell-inner plexiform layer (GCIPL) thickness.
- Standard automated perimetry (SAP) and microperimetry (MP) are key functional tests for evaluating visual sensitivity.
Purpose of the Study:
- To compare the structure-function relationship between GCIPL thickness (measured by SDOCT) and visual sensitivity (measured by SAP and MP) in the macula of glaucoma patients.
- To evaluate the concordance of SAP and MP in reflecting GCIPL changes in glaucoma.
Main Methods:
- A prospective study involving 45 control eyes and 60 glaucoma eyes.
- Visual sensitivity was assessed using SAP and MP within the central 10° macula.
- GCIPL thickness was measured using SDOCT, and structure-function relationships were analyzed using the Hood and Kardon model.
Main Results:
- The number of data points deviating from the Hood and Kardon model predictions was comparable between SAP and MP across all macular sectors.
- Statistical analysis revealed no significant differences (P > 0.05) in the structure-function relationship concordance between SAP and MP.
- Both perimetry methods showed similar agreement with SDOCT-derived GCIPL thickness measurements.
Conclusions:
- Visual sensitivity assessments using both SAP and MP exhibit a similar structure-function relationship with SDOCT-measured GCIPL thickness in glaucoma.
- This suggests that both SAP and MP are similarly effective in correlating with structural GCIPL changes in the macula in glaucoma.
