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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Related Experiment Video

Updated: Mar 28, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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Electroretinography in glaucoma diagnosis.

Laura J Wilsey1, Brad Fortune

  • 1Discoveries in Sight Research Laboratories, Devers Eye Institute and Legacy Research Institute, Legacy Health, Portland, Oregon, USA.

Current Opinion in Ophthalmology
|January 1, 2016
PubMed
Summary
This summary is machine-generated.

The pattern reversal electroretinogram (PERG) and photopic negative response (PhNR) can detect early, reversible vision dysfunction in glaucoma. These electroretinogram tests offer objective measures sensitive to glaucomatous damage.

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Using the Electroretinogram to Assess Function in the Rodent Retina and the Protective Effects of Remote Limb Ischemic Preconditioning
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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Vision Science

Background:

  • Electrophysiological measures of vision function are of significant interest in glaucoma research.
  • These measures have the potential to elucidate disease mechanisms and offer sensitive functional metrics.
  • The electroretinogram (ERG) is a key electrophysiological tool in this field.

Purpose of the Study:

  • To review recent literature on the electroretinogram (ERG).
  • To provide an update on the role of ERG in glaucoma diagnosis.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of electrophysiological data, specifically pattern reversal ERG (PERG) and photopic negative response (PhNR).

Main Results:

  • PERG and PhNR are objective measures of retinal ganglion cell function sensitive to glaucomatous damage.
  • Reduced PERG amplitude predicts future visual field conversion and retinal nerve fiber layer thinning.
  • Abnormalities in PERG and PhNR may represent reversible dysfunction in glaucoma.

Conclusions:

  • PERG and PhNR from the central macula can detect early-stage, reversible glaucomatous dysfunction.
  • These electroretinogram measures show promise for glaucoma diagnosis and risk stratification.