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Diesel exhaust particles and endothelial cells dysfunction: An update
A O Lawal1, L M Davids2, J L Marnewick3
1Oxidative Stress Research Centre, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville Campus, Bellville 7535, South Africa.
Summary
Exposure to diesel exhaust particles (DEPs) harms cardiovascular health by damaging endothelial cells. This review examines DEPs
Area of Science:
- Environmental Health
- Cardiovascular Science
- Toxicology
Background:
- Particulate matter (PM) exposure is linked to increased mortality, particularly cardiovascular causes.
- Diesel exhaust particles (DEPs) are significant components of PM, known to compromise endothelial cell integrity.
- Endothelial dysfunction is a critical factor in organ dysfunction and disease.
Purpose of the Study:
- To review scientific evidence linking DEP exposure to endothelial cell dysfunction in cardiovascular diseases.
- To explore the mechanisms underlying DEP-induced endothelial cell dysfunction.
- To discuss preventive and therapeutic strategies for mitigating DEP-related endothelial damage.
Main Methods:
- Literature review of epidemiological and experimental studies.
- Analysis of mechanisms of DEP toxicity on endothelial cells.
- Synthesis of current knowledge on cardiovascular impacts of DEPs.
Main Results:
- Consistent evidence shows DEPs disrupt endothelial monolayer integrity.
- DEP exposure is associated with various cardiovascular pathophysiological conditions.
- Multiple mechanisms contribute to DEP-induced endothelial dysfunction.
Conclusions:
- DEP exposure poses a significant threat to cardiovascular health via endothelial damage.
- Understanding the mechanisms is crucial for developing interventions.
- Preventive and therapeutic approaches are needed to combat DEP-induced cardiovascular risks.
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