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Related Concept Videos

Colloids and Suspensions01:17

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Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles visible to the naked eye or seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. The suspended particles in a suspension settle out after some time of mixing. The separation of particles from a suspension is...
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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
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Nanosuspension: Principles, Perspectives and Practices.

Sachin Kumar Singh1, Yogyata Vaidya, Monica Gulati

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Nano-sizing drugs into nanosuspensions improves solubility and bioavailability. This review covers production, characterization, and stability strategies for commercializing these advanced drug delivery systems.

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Nano-sizing hydrophobic drugs is a key strategy to enhance solubility and bioavailability.
  • Nanosuspensions offer unique advantages over other drug delivery approaches.
  • Significant advancements have enabled commercial production of stable nanosuspensions.

Purpose of the Study:

  • To review techniques for nanosuspension production and characterization.
  • To discuss the merits, limitations, and stability mechanisms of nanosuspensions.
  • To highlight strategies for overcoming stability and commercialization challenges.

Main Methods:

  • Review of literature on nanosuspension production techniques (e.g., media milling, high-pressure homogenization).
  • Analysis of characterization methods for nanosuspensions.
  • Examination of physicochemical stability mechanisms and commercialization strategies.

Main Results:

  • Nanosuspensions provide a versatile platform for improving drug properties.
  • Established methods facilitate the commercial production of stable nanosuspensions.
  • Understanding stability mechanisms is crucial for successful formulation.

Conclusions:

  • Nanosuspensions are a vital approach for addressing challenges with hydrophobic drugs.
  • Continued research into production and stability will drive further commercialization.
  • This review provides a comprehensive overview for researchers and developers in the field.