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Published on: June 7, 2013
Pharmacological Interactions on Blood Pressure Control in Arterial Hypertension, An Issue not to be Overlooked
Michele M Ciulla1, Chiara Benfenati, Enrico Gallazzi
1Laboratory of Clinical Informatics and Cardiovascular Imaging, Via F. Sforza, 35 20122 Milan, Italy. michele.ciulla@unimi.it.
Insights
Long-term hypertension management requires continuous monitoring due to side effects and drug interactions. Addressing these challenges is crucial for preventing cardiovascular disease and organ damage.
Area of Science:
- Cardiology
- Pharmacology
- Public Health
Background:
- Essential arterial hypertension management necessitates long-term strategies to prevent target organ damage and cardiovascular events.
- Current treatment paradigms face challenges including achieving target blood pressure, managing drug side effects, and addressing adverse drug reactions in an aging population.
Purpose of the Study:
- To evaluate the goals of antihypertensive therapy.
- To identify weak spots in current strategies, including side effects and poor therapy compliance.
- To review drug interactions impacting blood pressure control.
Main Methods:
- Literature review of antihypertensive therapy goals and challenges.
- Analysis of factors affecting treatment efficacy and patient compliance.
- Examination of drug interactions relevant to hypertension management.
Main Results:
- Achieving target blood pressure requires continuous monitoring and often combination therapies.
- Chronic use of antihypertensives can lead to side effects and adverse drug reactions.
- Drug interactions can interfere with blood pressure control and reduce treatment effectiveness.
Conclusions:
- Long-term hypertension management requires ongoing adaptation of strategies.
- Addressing side effects, compliance, and drug interactions is vital for effective cardiovascular risk reduction.
- Further research is needed to optimize prevention strategies for target organ damage and mortality.
Abstract:
Our vision of long-term treatment strategies for the prevention of target organ damage and eventually cardiovascular morbidity and mortality in essential arterial hypertension needs to be continually monitored and updated for at least three issues: 1--the achievement of target pressure required to obtain the expected benefit needs continuous monitoring, a dose adjustment of the drug and, often, the use of combination therapies; 2--the chronic use of certain drugs, even in combination, is associated with the possible onset of side effects; 3--increasing of population life expectancy is inevitably associated with in an increase in drugs use with the unavoidable occurrence of adverse drug reactions, some of which can interfere with blood pressure control. These issues, still poorly studied, pose considerable problems in applying proper strategies for prevention. In this review, we will evaluate the goals of antihypertensive therapy, and its weak spots, such as the frequent side effects, that lead to poor therapy compliance. Moreover, we will review the interactions between antihypertensive and drugs used for other common disease, and their importance in not achieving the expected blood pressure reduction.
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