Related Experiment Video
Updated: Mar 28, 2026
Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice
Published on: December 27, 2024
Estimating the Survival of Elderly Patients with Renal Cell Carcinoma Presenting with Malignant Spinal Cord
Dirk Rades1, Antonio J Conde-Moreno2, Jon Cacicedo3
1Department of Radiation Oncology, University of Lübeck, Lübeck, Germany rades.dirk@gmx.net.
Aim:
To develop a tool for predicting survival of elderly patients with malignant spinal cord compression (MSCC) from renal cell carcinoma.
Patients And Methods:
In 71 elderly patients, 10 factors were analyzed. Predictive scores were generated based on 6-month survival rates.
Results:
Longer interval from renal cell carcinoma diagnosis to MSCC (p=0.019), lack of visceral metastases (p<0.001), slower progression of motor deficits (p<0.001), ambulation (p<0.001) and better performance status (p=0.002) were positive predictors. On multivariate analysis, interval from renal cell carcinoma diagnosis to MSCC (p=0.022), visceral metastases (p<0.001), time to developing motor dysfunction (p=0.041), gait function (p=0.002) and performance status (p=0.017) remained significant. Predictive scores were 17 to 36 points. Four groups were created: 17-23, 24-26, 27-29 and 30-36 points. Six-month survival rates were 8%, 30%, 69% and 100%, respectively (p<0.001).
Conclusion:
This tool improves estimation of survival and personalized treatment options in elderly patients with MSCC from renal cell carcinoma.
