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Updated: Mar 28, 2026
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
Choriocarcinoma presenting with thyrotoxicosis
David Sotello1, Ana Marcella Rivas1, Victor J Test1
1Department of Internal Medicine (Sotello, Rivas), Division of Pulmonary/Critical Care Medicine (Test), and Division of Endocrinology (Lado-Abeal), Texas Tech University Health Science Center, Lubbock, Texas.
Abstract:
We describe a 26-year-old man with metastatic choriocarcinoma who presented with hyperthyroidism associated with elevated β-human chorionic gonadotropin (B-HCG) and respiratory failure secondary to diffuse lung metastasis. After the first cycle of chemotherapy, the concentration of B-HCG dramatically decreased and the patient became euthyroid, allowing us to discontinue antithyroid medications. The patient's hyperthyroidism was caused by stimulation of the thyroid gland by high B-HCG levels, as shown by the marked improvement of the patient's thyroid function panel after chemotherapy.
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