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Surgical prophylaxis and treatment of surgical infections with quinolones

C E Nord1

  • 1Department of Microbiology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden.

Reviews of Infectious Diseases
|July 1, 1989
PubMed

Insights

Intraabdominal infections are complex polymicrobial infections. New quinolones show promise for treating infections caused by enterobacteria and staphylococci, but additional agents are needed for streptococci and anaerobes.

Area of Science:

  • Surgical infections
  • Infectious diseases
  • Antimicrobial therapy

Background:

  • Intraabdominal infections are challenging due to their polymicrobial nature and varied locations.
  • These infections often arise from trauma, surgery, or gastrointestinal diseases.
  • Diagnosis and treatment can be complicated, necessitating effective antimicrobial strategies.

Purpose of the Study:

  • To evaluate the efficacy of new quinolones in treating intraabdominal infections.
  • To assess the role of new quinolones in surgical prophylaxis and treatment.
  • To determine appropriate antimicrobial combinations for polymicrobial intraabdominal infections.

Main Methods:

  • Review of existing studies on new quinolone use in surgical infections.
  • Analysis of microbial profiles in intraabdominal infections (aerobic, anaerobic, polymicrobial).
  • Assessment of clinical outcomes with new quinolone therapy.

Main Results:

  • New quinolones demonstrate successful treatment of surgical infections caused by enterobacteria and staphylococci.
  • Combined antimicrobial therapy is necessary when streptococci or anaerobic bacteria are present.
  • Adequate surgical drainage and antimicrobial treatment are crucial for improving outcomes.

Conclusions:

  • New quinolones are effective against specific bacterial pathogens in intraabdominal infections.
  • Tailored antimicrobial regimens are essential for comprehensive treatment of polymicrobial infections.
  • Further research is warranted to fully elucidate the role of new quinolones in surgical settings.

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