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Genetic association between CARD9 variants and inflammatory bowel disease was not replicated in a Chinese Han

Zhengting Wang1, Rong Fan1, Lei Wang1

  • 1Department of Gastroenterology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University Shanghai 200025, China.

International Journal of Clinical and Experimental Pathology
|January 2, 2016
PubMed

Insights

This study found no significant association between CARD9 gene variants and inflammatory bowel disease (IBD) in the Chinese Han population. Further research is needed to confirm these findings in diverse ethnic groups.

Area of Science:

  • Genetics
  • Gastroenterology
  • Immunology

Background:

  • Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is a group of chronic gastrointestinal disorders.
  • The CARD9 gene has been implicated in IBD susceptibility in some populations, but its role in the Chinese Han population remains unclear.

Purpose of the Study:

  • To investigate the association between CARD9 gene single nucleotide polymorphisms (SNPs) and IBD susceptibility in the Chinese Han population.
  • To replicate findings from previous studies suggesting a link between CARD9 and IBD.

Main Methods:

  • Genotyping of two specific CARD9 SNPs using polymerase chain reaction with sequence-specific primers.
  • Analysis of allele and genotype frequencies in 288 IBD patients (232 CD, 56 UC) and 274 healthy controls.

Main Results:

  • No statistically significant differences in allele or genotype frequencies of the studied CARD9 SNPs were observed between IBD patients and controls.
  • The investigated CARD9 SNPs were not found to be associated with an increased risk of developing CD or UC in this cohort.

Conclusions:

  • The studied CARD9 SNPs do not appear to contribute to IBD susceptibility in the Chinese Han population.
  • Larger-scale studies and investigations across different ethnicities are necessary to fully understand the potential role of CARD9 in IBD pathogenesis.
Abstract

Keywords:
CARD geneCrohn’s diseaseassociationinflammatory bowel diseasesulcerative colitis

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