Relationship between hWAPL polymorphisms and cervical cancer susceptibility
Li Li1, Gen-Long Jiao2, Shuang Qin3
1Shenzhen Guangming New District Center Hospital Shenzhen, Guangdong, China.
International Journal of Clinical and Experimental Pathology
|January 2, 2016
Summary
Genetic variations in the human wing-apart like (hWAPL) gene, specifically rs7083506 and rs11202058, are linked to cervical cancer risk. The T-A haplotype of these polymorphisms significantly increases susceptibility to cervical cancer.
Area of Science:
- Genetics
- Oncology
Background:
- Cervical cancer remains a significant global health concern.
- Understanding genetic predispositions is crucial for early detection and prevention strategies.
Purpose of the Study:
- To investigate the association between specific polymorphisms (rs7083506 and rs11202058) in the human wing-apart like (hWAPL) gene and cervical cancer susceptibility.
- To analyze the combined effect of these polymorphisms through haplotype analysis in relation to cervical cancer risk.
Main Methods:
- Genotyping using the Taqman probe method for hWAPL gene polymorphisms (rs7083506 and rs11202058).
- Case-control study involving 117 cervical cancer patients and 128 healthy controls.
- Linkage disequilibrium and haplotype analysis performed using Haploview software, with statistical analysis via the chi-squared test.
Main Results:
- The TT genotype of rs7083506 was found to increase cervical cancer susceptibility (OR=2.249, P<0.05).
- The A allele of rs11202058 was associated with increased cervical cancer risk (OR=1.502, P<0.05).
- The T-A haplotype demonstrated a significant correlation with cervical cancer, increasing susceptibility by 1.78 times (P<0.05).
Conclusions:
- The studied polymorphisms (rs7083506 and rs11202058) in the hWAPL gene are associated with cervical cancer.
- The T-A haplotype of hWAPL gene polymorphisms is a significant risk factor for cervical cancer development.
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