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The new quinolones: back to the future.
1Department of Biotechnology, Institut Pasteur, Paris, France.
Reviews of Infectious Diseases
|July 1, 1989
Summary
New quinolone antimicrobials show promise for infectious diseases but require further study. Prudent use is essential due to emerging resistant strains impacting their therapeutic effectiveness.
Area of Science:
- Microbiology
- Pharmacology
- Molecular Biology
Background:
- New quinolone derivatives represent a significant advancement in treating infectious diseases.
- Despite their promise, a comprehensive understanding of their biological properties is still developing.
Purpose of the Study:
- To explore the mode of action of new quinolone derivatives at the target level.
- To discuss the implications for designing topoisomerase inhibitors for both prokaryotic and eukaryotic systems.
- To address the emergence of resistant strains and their impact on quinolone efficacy.
Main Methods:
- Detailed analyses of the mechanism of action.
- Examination of biological properties.
- Review of emerging antimicrobial resistance patterns.
Main Results:
- Quinolones target topoisomerases, with implications for inhibitor design.
- Antimicrobial resistance to quinolones has emerged rapidly.
- Resistance threatens the long-term therapeutic potential of these agents.
Conclusions:
- Further research into quinolone mechanisms is crucial.
- The emergence of resistance necessitates careful clinical application.
- Prudent use of quinolones is vital to preserve their future clinical benefits.