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Related Experiment Video

Updated: Mar 28, 2026

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Single-stage breast reconstruction using Strattice™: A retrospective study.

R E G Dikmans1, F El Morabit1, M J Ottenhof2

  • 1Department of Plastic, Reconstructive & Hand Surgery, VU University Medical Center, Amsterdam, The Netherlands.

Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS
|January 3, 2016
PubMed
Summary
This summary is machine-generated.

This study found a high complication rate in single-stage breast reconstruction using Strattice, a porcine acellular dermal matrix. Further research is needed to confirm its effectiveness and guide patient selection for this breast reconstruction method.

Keywords:
Acellular dermal matrixBreast reconstructionImplant based reconstructionSingle-stage breast reconstructionStrattice

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Area of Science:

  • Plastic Surgery
  • Regenerative Medicine
  • Oncology

Background:

  • Strattice, a porcine acellular dermal matrix, is used to improve implant coverage in breast reconstruction.
  • Evidence supporting Strattice's efficacy in breast reconstruction is currently limited.
  • This study evaluates clinical outcomes of implant-based breast reconstruction augmented with Strattice.

Purpose of the Study:

  • To assess the clinical outcomes of single-stage implant-based breast reconstruction using Strattice.
  • To identify complication rates and reoperation necessity in patients receiving Strattice.
  • To explore factors influencing the success of Strattice in breast reconstruction.

Main Methods:

  • Retrospective chart review of patients undergoing single-stage breast reconstruction with Strattice (2010-2014).
  • Inclusion of cases from eight Dutch centers following oncologic or prophylactic mastectomy.
  • Data collection on demographics, treatment, and outcomes; descriptive statistics and Fisher's exact test were used.

Main Results:

  • Eighty-eight patients (110 breasts) underwent reconstruction; 69.1% for therapeutic mastectomy, 30.9% for prophylactic.
  • High complication rates reported: seroma (20.9%), skin necrosis (20.0%), wound dehiscence (11.8%), erythema (14.5%), infection (11.8%).
  • Reoperation was required in 22.7% of breasts, with 11.8% necessitating implant explantation.

Conclusions:

  • The overall complication rate in this cohort was high (78%), with significant reoperation rates.
  • While complications were often minor, implant explantation occurred in 11.8% of cases.
  • Patient selection, surgeon experience, and early complication management are critical; further randomized trials are needed to validate Strattice use.