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Meta-Analysis on the Correlation Between APOM rs805296 Polymorphism and Risk of Coronary Artery Disease

HongYan Sun1, Dong Shen1, ChunHong Zhang1

  • 1Department of Cardiology, The First Affiliated Hospital of PLA General Hospital, Beijing, China (mainland).

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
|January 3, 2016
PubMed
Abstract

Insights

The apolipoprotein M gene (ApoM) rs805296 polymorphism is linked to a higher risk of coronary artery disease (CAD). This meta-analysis confirms this association, providing a clearer understanding of the genetic factors contributing to CAD.

Area of Science:

  • Genetics and Cardiovascular Disease
  • Molecular Epidemiology
  • Biomarker Discovery

Background:

  • Coronary artery disease (CAD) is a leading cause of mortality worldwide.
  • The role of genetic variations, such as apolipoprotein M gene (ApoM) rs805296 polymorphism, in CAD risk is under investigation.
  • Inconsistent findings necessitate a comprehensive meta-analysis to clarify the association.

Purpose of the Study:

  • To synthesize existing research on the ApoM rs805296 polymorphism and its association with coronary artery disease (CAD) risk.
  • To provide a more definitive conclusion regarding the impact of this specific genetic variant on CAD development.
  • To consolidate data from multiple studies for enhanced statistical power.

Main Methods:

  • Systematic literature search across PubMed, EMBASE, and CNKI databases.
  • Inclusion of 7 relevant studies for meta-analysis.
  • Statistical assessment using odds ratios (ORs) and 95% confidence intervals (95% CIs) under fixed- or random-effects models.
  • Evaluation of heterogeneity, Hardy-Weinberg equilibrium, sensitivity, and publication bias.

Main Results:

  • The ApoM rs805296 polymorphism was associated with an increased risk of CAD across all genetic models analyzed.
  • Specific contrasts showed significant risk increases: CC vs TT (OR=2.13), CC+TC vs TT (OR=1.80), CC vs TT+TC (OR=1.91), C vs T (OR=1.72), and TC vs TT (OR=1.78).
  • Pooled results indicate a consistent elevation in CAD risk linked to this polymorphism.

Conclusions:

  • The apolipoprotein M gene (ApoM) rs805296 polymorphism is identified as a potential risk factor for developing coronary artery disease (CAD).
  • This finding contributes to understanding the genetic predisposition to CAD.
  • Further research may explore the mechanisms underlying this genetic association.

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