Related Experiment Video
Updated: Mar 28, 2026

Experimental Human Pneumococcal Carriage
Published on: February 15, 2013
[Positive urine pneumococcal antigen test and vaccination]
Alejandro Salinas-Botrán1, Patricia Martín-Rico1, Antonio Valdivia2
1Servicio de Medicina Interna, Hospital de Denia, Denia, Alicante, España.
Introduction And Objective:
Although urine pneumococcal antigen is an useful test, it has false positives such as pneumococcal vaccination.
Material And Methods:
Positive urine pneumococcal antigen in Hospital de Denia (January-February/2015). We studied epidemiological, radiological and microbiological variables as well as previous pneumococcal vaccination (neumo-23 and/or neumo-13).
Results:
Urine pneumococcal antigen test was positive in 12.4% of 385 cases. Only 33.3% of positive cases had pneumonia in chest X-ray, and 35.4% of patients had previous pneumococcal vaccination. In most cases (87.5%), an antibiotic was prescribed.
Conclusions:
Pneumococcal vaccination can produce a false positive result in the urine pneumococcal antigen test in clinical practice, leading to an unnecessary prescription of antibiotics.
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