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A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

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Microbubble generation by piezotransducer for biological studies.

W Zhu¹, M Alkhazal², M Cho³

¹Department of Applied Science and Technology, Saint Peter's University, Jersey City, New Jersey 07306, USA.

The Review of Scientific Instruments

|January 3, 2016

Summary

Researchers developed a novel system to isolate the effects of microbubbles from shock waves in cell damage studies. This allows for clearer understanding of bubble-induced injury mechanisms in conditions like mild traumatic brain injury.

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Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

Area of Science:

Biophysics
Cell Biology
Biomedical Engineering

Background:

Blast waves and shock waves can cause cell damage, particularly in mild traumatic brain injury (mTBI).
Microbubble collapse is a suspected contributor to mTBI-related cellular damage, affecting cell adhesion and biomechanics.
Existing methods struggle to differentiate the effects of microbubbles from the accompanying pressure waves.

Purpose of the Study:

To design and construct a low-profile system capable of generating microbubbles.
To differentiate the cellular impact of microbubbles from that of shock waves.
To investigate the specific role of microbubbles in cellular damage.

Main Methods:

A piezoelectric transducer system was engineered for generating microbubbles.
The system utilizes flat or spherical focusing transducers within a cuvette containing cell-culture medium.
A specific setup minimizes direct wave impact on cells, isolating bubble-cell interactions.

Main Results:

The system successfully generated microbubbles with radii ranging from 10 to 100 μm, predominantly 20-30 μm.
The experimental design effectively separated the effects of microbubbles from pressure waves on cells.
Observed effects included cell detachment and alterations in focal adhesion and biomechanics.

Conclusions:

The developed piezoelectric transducer system provides a method to isolate microbubble effects from shock waves.
This system enables a clearer understanding of microbubble-induced cellular damage mechanisms.
Findings contribute to understanding cellular injury in mild traumatic brain injury and related fields.