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The chromatographic performance of flow-through particles: A computational fluid dynamics study.
Wim Smits1, Kazuki Nakanishi2, Gert Desmet1
1Vrije Universiteit Brussel, Department of Chemical Engineering, Pleinlaan 2, 1050 Brussels, Belgium.
Journal of Chromatography. A
|January 3, 2016
Summary
Flow-through particles, simulated using computational fluid dynamics, show enhanced mass transfer but higher flow resistance. This offers no significant kinetic performance gain over standard fully porous particles.
Area of Science:
- Chromatography
- Chemical Engineering
- Fluid Dynamics
Background:
- Flow-through particles are a novel packing material for chromatography.
- Their performance compared to traditional fully porous particles requires detailed investigation.
Purpose of the Study:
- To computationally simulate and analyze the performance of flow-through particles.
- To compare their kinetic performance and plate heights against fully porous particles.
Main Methods:
- Computational fluid dynamics (CFD) simulations were employed to model flow behavior.
- Simulations calculated flow fields around and within particles.
- Plate heights were simulated and compared between particle types.
Main Results:
- Intra-particle flow in flow-through particles enhances mass transfer, reducing total plate height.
- An empirical model for mass transfer enhancement was developed and validated.
- Columns packed with flow-through particles exhibited higher flow resistance.
Conclusions:
- Flow-through particles demonstrate improved mass transfer characteristics.
- However, increased flow resistance negates potential kinetic performance benefits.
- No significant kinetic performance advantage was observed over fully porous particles.
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