Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

How does protein folding get started?

R L Baldwin

    Trends in Biochemical Sciences
    |July 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    Protein folding initiation is explored through three models: hydrophobic collapse, secondary structure formation, and specific interactions. The study discusses whether these protein folding pathways are contradictory or complementary.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Estimation of genetic parameters for feed efficiency traits using random regression models in dairy cattle.

    Journal of dairy science·2023
    Same author

    Multiple-trait random regression modeling of feed efficiency in US Holsteins.

    Journal of dairy science·2022
    Same author

    Effect of milking frequency and α-tocopherol plus selenium supplementation on sheep milk lipid composition and oxidative stability.

    Journal of dairy science·2019
    Same author

    Reducing gut effects from Cryptosporidium parvum infection in dairy calves through prophylactic glucagon-like peptide 2 therapy or feeding of an artificial sweetener.

    Journal of dairy science·2017
    Same author

    Glucagon-like peptide 2 and its beneficial effects on gut function and health in production animals.

    Domestic animal endocrinology·2016
    Same author

    Role of rumen butyrate in regulation of nitrogen utilization and urea nitrogen kinetics in growing sheep.

    Journal of animal science·2015
    Same journal

    Intrinsically disordered regions in eukaryotic mRNA decay pathways.

    Trends in biochemical sciences·2026
    Same journal

    A unified mechanism of phosphate export across eukaryotes through EXS domain-containing proteins.

    Trends in biochemical sciences·2026
    Same journal

    Drugging the proteome via large-scale chemoproteomics.

    Trends in biochemical sciences·2026
    Same journal

    Peptideins: Navigating the gray zone of the proteome.

    Trends in biochemical sciences·2026
    Same journal

    A metabolon channels nicotine biosynthesis.

    Trends in biochemical sciences·2026
    Same journal

    Better call chaperone.

    Trends in biochemical sciences·2026
    See all related articles

    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Physical Chemistry

    Background:

    • Protein folding is crucial for biological function.
    • Understanding protein folding initiation is a key challenge in molecular biology.
    • Recent experimental data provide new insights into folding pathways.

    Purpose of the Study:

    • To evaluate three distinct models for protein folding initiation.
    • To analyze the roles of hydrophobic collapse, secondary structure formation, and specific interactions.
    • To determine the relationship (contradictory or complementary) between these folding models.

    Main Methods:

    • Review and analysis of recent experimental findings.
    • Theoretical consideration of proposed protein folding mechanisms.

    Related Experiment Videos

  • Comparative analysis of different initiation models.

    • Main Results:

    • Experimental evidence supports multiple initiation pathways for protein folding.
    • Hydrophobic collapse, secondary structure formation, and specific interactions can all play roles.
    • The interplay between these factors is context-dependent.

    Conclusions:

    • The three models of protein folding initiation are not mutually exclusive.
    • These models are likely complementary, with their relative importance varying.
    • A comprehensive understanding requires considering the integration of these mechanisms.