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Related Concept Videos

Sutures of the Skull01:22

Sutures of the Skull

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The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
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Cranial Bones: Superior and Posterior View01:14

Cranial Bones: Superior and Posterior View

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The superior view of the cranium shows the frontal and paired parietal bones.
The frontal bone is the single bone that forms the forehead. At its anterior midline, between the eyebrows, there is a slight depression called the glabella. The frontal bone also forms the supraorbital margin of the orbit. Near the middle of this margin is the supraorbital foramen, the opening that provides passage for a sensory nerve to the forehead. The frontal bone is thickened just above each supraorbital margin,...
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Overview of the Skull01:08

Overview of the Skull

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The cranium (skull) is the skeletal structure of the head that supports the face and protects the brain. It is subdivided into the facial bones and the brain case, or cranial vault. The facial bones underlie the facial structures, form the nasal cavity, enclose the eyeballs, and support the teeth of the upper and lower jaws.
The cranial vault surrounds and protects the brain and houses the middle and inner ear structures. This cavity is bounded superiorly by the rounded top of the skull, which...
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Related Experiment Video

Updated: Mar 28, 2026

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
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Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

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Skull base chondrosarcoma.

Mohammed Awad1, Andrew James Gogos2, Andrew H Kaye2

  • 1Department of Neurosurgery, The Royal Melbourne Hospital, 300 Grattan Street, Parkville, VIC 305, Australia.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|January 4, 2016
PubMed
Summary
This summary is machine-generated.

Intracranial chondrosarcomas are rare skull base tumors. Maximal safe surgical resection followed by radiotherapy for Grade II and III lesions is recommended, with no role for chemotherapy.

Keywords:
ChondrosarcomaIntracranialSkull base

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Area of Science:

  • Neurosurgery
  • Oncology
  • Pathology

Background:

  • Intracranial chondrosarcomas are rare neoplasms, representing approximately 0.1% of all brain tumors.
  • These tumors predominantly occur at the skull base, posing significant surgical and oncological challenges.
  • While often slow-growing, higher-grade (II and III) lesions necessitate specific management strategies.

Observation:

  • Two illustrative cases from Royal Melbourne Hospital highlight varied presentations and outcomes of skull base chondrosarcomas.
  • Diagnostic difficulties can arise due to the diverse clinical and radiological features.
  • Literature review of clinical, radiological, and histological characteristics is presented.

Findings:

  • Maximal safe surgical resection is the primary treatment modality.
  • Radiotherapy is indicated for Grade II and III chondrosarcomas.
  • Current evidence does not support the use of chemotherapy for intracranial chondrosarcomas.

Implications:

  • Treatment decisions must balance oncological goals with the preservation of neurological function.
  • Adherence to maximal safe resection and radiotherapy guidelines can improve outcomes.
  • Further research may elucidate novel therapeutic targets for aggressive chondrosarcoma subtypes.