Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Primary hyperoxaluria].

S D Ladefoged, H E Jørgensen

    Ugeskrift for Laeger
    |July 17, 1989
    PubMed
    Summary
    This summary is machine-generated.

    Primary hyperoxaluria (PHO) is a genetic metabolic disorder causing kidney stones and failure. Combined liver and kidney transplant is the optimal treatment for PHO renal failure.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A randomized and double-blind comparison of isradipine and spirapril as monotherapy and in combination on the decline in renal function in patients with chronic renal failure and hypertension.

    Clinical nephrology·2001
    Same author

    [Quality assurance of hemodialysis. Results after five years].

    Ugeskrift for laeger·2001
    Same author

    Growth hormone, insulin-like growth factors and their binding proteins in adult hemodialysis patients treated with recombinant human growth hormone.

    Clinical nephrology·1999
    Same author

    Glomerular filtration rate estimated from the uptake phase of 99mTc-DTPA renography in chronic renal failure.

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·1999
    Same author

    Dialysis catheter-related septicaemia--focus on Staphylococcus aureus septicaemia.

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·1998
    Same author

    [The influence of antihypertensive treatment on progression of chronic nepropathy].

    Ugeskrift for laeger·1997
    Same journal

    [Mosaicism as a cause of Cowden syndrome].

    Ugeskrift for laeger·2026
    Same journal

    [Thyrotoxic crisis with cardiogenic shock].

    Ugeskrift for laeger·2026
    Same journal

    [Mindfulness-based cognitive therapy in the treatment of depression].

    Ugeskrift for laeger·2026
    Same journal

    [Fitness].

    Ugeskrift for laeger·2026
    Same journal

    [Risk of developing cataract related to fluoroscopy].

    Ugeskrift for laeger·2026
    Same journal

    [Obturator hernia with small bowel ileus presenting as hip pain in an elderly woman].

    Ugeskrift for laeger·2026
    See all related articles

    Area of Science:

    • Biochemistry
    • Genetics
    • Nephrology

    Background:

    • Primary hyperoxaluria (PHO) is a rare, inherited disorder of glyoxylate metabolism.
    • It results from a deficiency in the liver enzyme alanine glyoxylate transaminase.
    • PHO leads to the accumulation of oxalate, causing severe kidney damage.

    Observation:

    • Key symptoms include recurrent kidney stones, nephrocalcinosis, and progressive renal failure.
    • Advanced PHO can lead to systemic oxalosis, affecting bones, vasculature, and the heart.
    • Current treatments like dialysis and single organ transplantation offer poor outcomes.

    Findings:

    • Combined liver and renal transplantation effectively corrects the metabolic defect in PHO.
    • This combined approach normalizes oxalate excretion and improves patient prognosis.

    Related Experiment Videos

  • Transplantation before severe renal decline (creatinine clearance < 10-20 ml/min) is crucial.

    • Implications:

    • Combined liver-kidney transplantation represents the optimal therapeutic strategy for end-stage renal disease due to PHO.
    • Early transplantation is recommended to prevent systemic oxalate deposition and complications.
    • This intervention offers a chance for improved survival and quality of life for PHO patients.