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Is steroids therapy effective in treating phimosis? A meta-analysis

Jiaming Liu1, Jin Yang2, Yuntian Chen3

  • 1Department of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

International Urology and Nephrology
|January 4, 2016
PubMed

Insights

Topical steroid therapy is more effective for treating childhood phimosis than placebo or manual reduction. This systematic review provides evidence for clinical options before circumcision.

Area of Science:

  • Pediatric Urology
  • Dermatology
  • Evidence-Based Medicine

Background:

  • Phimosis is a common condition in pediatric patients.
  • Treatment options for phimosis include topical steroids, manual reduction, and circumcision.
  • The efficacy of topical steroids requires systematic evaluation.

Purpose of the Study:

  • To systematically review the therapeutic efficacy of topical steroids in children with phimosis.
  • To provide data supporting clinical decisions for pediatric phimosis management.
  • To compare topical steroid therapy with placebo and manual reduction.

Main Methods:

  • Systematic review of original studies on topical steroid therapy for pediatric phimosis.
  • Searched literature up to August 2014.
  • Meta-analysis performed using REVMAN 5.2 software with quality assessment via Cochrane handbook.

Main Results:

  • Eleven studies with 1669 patients were included.
  • Topical steroids showed significantly higher efficacy compared to placebo or manual reduction (OR 7.46, p < 0.00001).
  • Subgroup analyses confirmed significant efficacy against both placebo (OR 5.04, p < 0.00001) and manual reduction (OR 16.28, p < 0.00001).

Conclusions:

  • Topical steroid therapy is a more effective treatment for pediatric phimosis than placebo or manual reduction.
  • Topical steroids can be considered as a treatment option prior to circumcision.
  • Further research may be needed to determine optimal steroid types and dosages.
Abstract

Keywords:
Meta-analysisPediatric phimosisPhimosisTopical steroids

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