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A small molecule probe reveals declined mitochondrial thioredoxin reductase activity in a Parkinson's disease model
Yaping Liu1, Huilong Ma1, Liangwei Zhang1
1State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. fangjg@lzu.edu.cn.
Chemical Communications (Cambridge, England)
|January 5, 2016
Abstract:
The first off-on probe, Mito-TRFS, for imaging the mitochondrial thioredoxin reductase (TrxR2) in live cells was reported. In a cellular model of Parkinson's disease (PD), Mito-TRFS staining discloses a drastic decline of the TrxR2 activity, providing a mechanistic link of TrxR2 dysfunction to the etiology of PD.
