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[Captopril from Pharmachem in the treatment of arterial hypertension]
Insights
Captopril effectively treats all stages of hypertension in outpatients over six months. This study found significant improvements in blood pressure with manageable side effects, demonstrating its therapeutic potential.
Area of Science:
- Cardiology
- Pharmacology
Context:
- Hypertension management in outpatient settings.
- Evaluation of captopril efficacy and safety.
Purpose:
- To assess the effectiveness of captopril in treating different stages of arterial hypertension.
- To determine optimal dosing and identify potential side effects.
Summary:
- Thirty hypertensive patients received captopril for six months, with dosages adjusted up to 150 mg daily.
- Excellent or good results were observed in 86.7% of patients.
- Four patients achieved normal blood pressure with the addition of chlorthalidone.
- Observed side effects included minor changes in leukocytes, uric acid, and proteinuria.
Impact:
- Captopril demonstrates high efficacy as monotherapy or in combination with diuretics for all hypertension stages.
- Provides evidence for captopril's role in long-term outpatient hypertension management.
- Highlights the need for monitoring potential side effects during treatment.
Abstract:
30 hypertensive patients were treated in outpatients conditions for a 6 month period with captopril "Pharmachem". The patients were classified in accordance with the degree of the arterial hypertension into three groups: light hypertension--II patients, moderate hypertension 13 patients and severe hypertension--6 patients. Captopril was applied the first two weeks in a dose of 25 mg 3 times daily. When there was no effect the dose was increased every two weeks with 25 mg daily up to a 150 mg daily dose. A very good result was achieved in 11 patients (36.7%) and in 15 patients (50%) the result was considered good. In 4 patients the arterial pressure fell to normal after the addition of chlorthalidone. The following side effects were observed: decrease of the leucocyte number in reference ranges, insignificant increase of the uric acid in reference ranges, proteinuria below 1 gr/24 h. Captopril "Pharmachem" applied alone or in combination with a diuretic is a very efficient drug for the treatment of all stages of arterial hypertension.