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An evolutionary change in diagnostic virology.

M A Chernesky1

  • 1McMaster University Regional Virology and Chlamydiology Laboratories, St Joseph's Hospital, Hamilton, Ontario, Canada.

The Yale Journal of Biology and Medicine
|March 1, 1989
PubMed
Summary
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Diagnostic virology has evolved from early microscopy to advanced techniques like nucleic acid probes. This review examines scientific and societal shifts impacting viral diagnosis and the field's adaptation.

Area of Science:

  • Medical microbiology
  • Infectious disease diagnostics
  • Virology

Background:

  • Early viral diagnostics relied on microscopy.
  • Animal and egg inoculation were primary methods before the 1950s.
  • Tissue culture and serology revolutionized diagnostic virology in the mid-20th century.

Purpose of the Study:

  • To review the historical evolution of diagnostic virology.
  • To discuss the impact of scientific and societal changes on the field.
  • To examine how diagnostic virology has adapted to these influences.

Main Methods:

  • Historical review of diagnostic virology techniques.
  • Analysis of scientific advancements and societal trends.
  • Examination of the response of diagnostic virology.

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Main Results:

  • Diagnostic virology progressed from microscopy to tissue culture, serology, and rapid molecular methods.
  • Technological advancements like electron microscopy, immunoassays, and nucleic acid probes have enhanced speed and accuracy.
  • The field has continuously adapted to scientific discoveries and societal needs.

Conclusions:

  • Diagnostic virology has undergone significant transformation over the past century.
  • Modern rapid methods are crucial for timely laboratory decisions and patient care.
  • The discipline's ability to adapt ensures its continued relevance in combating viral infections.