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Epac Activation Regulates Human Mesenchymal Stem Cells Migration and Adhesion.

Jiao-Le Yu1,2, Ruixia Deng1, Sookja K Chung3,4

  • 1Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong Special Administration Region, People's Republic of China.

Stem Cells (Dayton, Ohio)
|January 5, 2016
PubMed
Summary

Enhancing human mesenchymal stem cell (hMSC) homing is crucial for therapy. Activating Exchange protein directly activated by cAMP (Epac) boosts hMSC migration and adhesion, improving homing efficiency.

Keywords:
Cell migrationMarrow stromal stem cellsMesenchymal stem cellsSDF-1

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