Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

In Vitro Drug Dissolution: Compendial Testing Models II01:09

In Vitro Drug Dissolution: Compendial Testing Models II

531
Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients,...
531
In Vitro Drug Dissolution: Compendial Testing Models I01:13

In Vitro Drug Dissolution: Compendial Testing Models I

472
Compendial dissolution methods are standardized procedures defined by pharmacopeias to evaluate the rate at which a drug dissolves in a specific medium. These methods ensure batch-to-batch consistency, enable quality control, and support the prediction of drug bioavailability. They are critical for both immediate and modified-release drug products.The apparatuses used for dissolution testing differ in their design and mechanical function, but all aim to simulate the physiological environment of...
472
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

754
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
754
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules01:18

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules

403
Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
403
In Vitro Drug Dissolution: Alternative Methods01:17

In Vitro Drug Dissolution: Alternative Methods

337
Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
337

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevalence of suicidal ideation and its correlates in young and elderly patients with chronic schizophrenia.

Journal of psychiatric research·2025
Same author

The role of the Nrf2 pathway in inhibiting ferroptosis in kidney disease and its future prospects.

Pathology, research and practice·2025
Same author

Dysregulation of lipid metabolism in chronic kidney disease and the role of natural products.

Naunyn-Schmiedeberg's archives of pharmacology·2024
Same author

Reducing VEGFB expression regulates the balance of glucose and lipid metabolism in mice via VEGFR1.

Molecular medicine reports·2022
Same author

Identification and characterization of two novel cathelicidins from the frog <i>Odorrana livida</i>.

Zoological research·2018
Same author

Effects of C-terminal amidation and heptapeptide ring on the biological activities and advanced structure of amurin-9KY, a novel antimicrobial peptide identified from the brown frog, <i>Rana kunyuensis</i>.

Zoological research·2018

Related Experiment Video

Updated: Mar 28, 2026

Finite Element Modeling for the Simulation of the Quasi-Static Compression of Corrugated Tapered Tubes
06:34

Finite Element Modeling for the Simulation of the Quasi-Static Compression of Corrugated Tapered Tubes

Published on: January 6, 2023

3.4K

Simulation and evaluation of tablet-coating burst based on finite element method.

Yan Yang1, Juan Li1, Kong-Song Miao1

  • 1a School of Pharmacy , Zhejiang University of Technology , Hangzhou , China.

Drug Development and Industrial Pharmacy
|January 5, 2016
PubMed
Summary

Finite element analysis accurately simulates coated tablet burst behavior. Key factors like swelling pressure and geometry predict coating failure, enabling optimized drug delivery design.

Keywords:
Finite element simulationgeometrical modelswelling pressuretablet-coating burst behavior

More Related Videos

Knowledge Based Cloud FE Simulation of Sheet Metal Forming Processes
11:05

Knowledge Based Cloud FE Simulation of Sheet Metal Forming Processes

Published on: December 13, 2016

12.8K
Formation of Dispersible Taohong Siwu Tablets
05:44

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

2.2K

Related Experiment Videos

Last Updated: Mar 28, 2026

Finite Element Modeling for the Simulation of the Quasi-Static Compression of Corrugated Tapered Tubes
06:34

Finite Element Modeling for the Simulation of the Quasi-Static Compression of Corrugated Tapered Tubes

Published on: January 6, 2023

3.4K
Knowledge Based Cloud FE Simulation of Sheet Metal Forming Processes
11:05

Knowledge Based Cloud FE Simulation of Sheet Metal Forming Processes

Published on: December 13, 2016

12.8K
Formation of Dispersible Taohong Siwu Tablets
05:44

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

2.2K

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Computational Mechanics

Background:

  • Coated tablets are crucial for controlled drug release.
  • Understanding tablet coating burst behavior is essential for formulation design.
  • Predictive modeling can optimize tablet performance.

Purpose of the Study:

  • To simulate and evaluate the burst behavior of coated tablets.
  • To identify key factors influencing coating failure.
  • To validate a computational model against experimental data.

Main Methods:

  • Development of 3D finite element models using ANSYS software.
  • Measurement of core swelling pressure and polymer film mechanical properties.
  • Validation of models using experimental burst data.

Main Results:

  • Simulations accurately predicted coating burst and failure locations.
  • Internal swelling pressure, corner radius, and thickness were identified as critical factors.
  • A linear relationship between internal pressure and maximum stress was established.

Conclusions:

  • Finite element method (FEM) is a viable tool for simulating coated tablet burst behavior.
  • The validated model can predict coating failure under various conditions.
  • This approach aids in optimizing coated tablet design for desired drug release profiles.