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Related Concept Videos

Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

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Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
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Oral Drug Delivery Systems: Continuous-Release Systems01:26

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Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
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Modified-Release Drug Delivery Systems: Overview01:19

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Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
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Drug Delivery: Miscellaneous Routes01:22

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
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Modified-Release Drug Delivery Systems: Influencing Factors01:20

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Modified-release drug delivery systems are designed to optimize the therapeutic effect of drugs by minimizing side effects, reducing the dosage required, and controlling drug release to align with pharmacokinetic and pharmacodynamic needs. The system depends on two key factors: the drug's release from the formulation and its movement through the body to the target site. Unlike conventional dosage forms, where absorption is the limiting step, the rate of drug release is the key determinant in...
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High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
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Successful interventions in decreasing oxycodone CR prescriptions within an underserved population.

Nipa R Shah1, Judella Haddad-Lacle1, Thanh Hogan2

  • 1Community Health and Family Medicine, University of Florida, Jacksonville, Florida.

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Implementing a patient-centered pain management protocol significantly reduced inappropriate oxycodone controlled release (CR) prescriptions by 75% in an uninsured population. This intervention improved prescribing practices without negatively impacting patient satisfaction.

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Area of Science:

  • Population Health
  • Pain Management
  • Pharmacoeconomics

Background:

  • Inappropriate prescribing of oxycodone controlled release (CR) poses a significant public health challenge, particularly within vulnerable, uninsured populations.
  • Patient-centered medical home models offer a framework for improving chronic pain management and medication stewardship.

Purpose of the Study:

  • To decrease the quantity of inappropriate oxycodone CR prescriptions within an uninsured patient population.
  • To implement and evaluate an intervention based on population health and patient-centered medical home guidelines.

Main Methods:

  • A prospective interventional study was conducted at the University of Florida Community Health and Family Medicine Department Total Care Clinic.
  • Patients with chronic nonmalignant pain, who were uninsured, received care under a new structured, step-wise pain management protocol and an enhanced Controlled Substance User Agreement.
  • Collaboration between pharmacists and primary care providers was integral to the intervention.

Main Results:

  • Oxycodone CR prescriptions decreased by 75%, from over 40 per month to approximately 10 per month.
  • The total number of oxycodone CR tablets prescribed also decreased by 75%, from over 2,500 to around 600 monthly.
  • Trends indicated a reduction in other long-acting opioids, and patient satisfaction remained stable with no significant complaints.

Conclusions:

  • Implementing specific criteria for oxycodone CR prescribing within a unified, patient-centered practice model led to a significant reduction in prescriptions.
  • This approach effectively addressed inappropriate opioid prescribing in an underserved population.
  • The intervention demonstrated the successful integration of population health principles into clinical practice for chronic pain management.