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Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
Published on: September 20, 2017
The Prodrug Approach: A Successful Tool for Improving Drug Solubility
Daniela Hartmann Jornada1, Guilherme Felipe dos Santos Fernandes2, Diego Eidy Chiba3
1Faculdade de Ciências Farmacêuticas, UNESP-University Estadual Paulista, Rodovia Araraquara Jaú Km 01, 14801-902 Araraquara, São Paulo, Brasil. daniela.dhj@gmail.com.
Abstract:
Prodrug design is a widely known molecular modification strategy that aims to optimize the physicochemical and pharmacological properties of drugs to improve their solubility and pharmacokinetic features and decrease their toxicity. A lack of solubility is one of the main obstacles to drug development. This review aims to describe recent advances in the improvement of solubility via the prodrug approach. The main chemical carriers and examples of successful strategies will be discussed, highlighting the advances of this field in the last ten years.
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