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Targeted Radionuclide Therapy of Human Tumors
Sergey V Gudkov1,2,3, Natalya Yu Shilyagina4, Vladimir A Vodeneev5
1Laboratory of Optical Theranostics, Lobachevsky Nizhny Novgorod State University, Gagarin Ave. 23, Nizhny Novgorod 603950, Russia. S_makariy@rambler.ru.
Abstract:
Targeted radionuclide therapy is one of the most intensively developing directions of nuclear medicine. Unlike conventional external beam therapy, the targeted radionuclide therapy causes less collateral damage to normal tissues and allows targeted drug delivery to a clinically diagnosed neoplastic malformations, as well as metastasized cells and cellular clusters, thus providing systemic therapy of cancer. The methods of targeted radionuclide therapy are based on the use of molecular carriers of radionuclides with high affinity to antigens on the surface of tumor cells. The potential of targeted radionuclide therapy has markedly grown nowadays due to the expanded knowledge base in cancer biology, bioengineering, and radiochemistry. In this review, progress in the radionuclide therapy of hematological malignancies and approaches for treatment of solid tumors is addressed.
Insights
Targeted radionuclide therapy offers a precise cancer treatment with minimal collateral damage. This nuclear medicine approach utilizes molecular carriers to deliver radionuclides directly to cancer cells, improving systemic therapy for various malignancies.
Area of Science:
- Nuclear medicine
- Oncology
- Radiochemistry
Background:
- Targeted radionuclide therapy is a rapidly advancing field within nuclear medicine.
- It offers an alternative to conventional external beam therapy, minimizing damage to healthy tissues.
- This therapy enables precise drug delivery to neoplastic malformations and metastatic cells.
Purpose of the Study:
- To review the progress in radionuclide therapy for hematological malignancies.
- To discuss current approaches for treating solid tumors using targeted radionuclide therapy.
- To highlight the growing potential of this cancer treatment modality.
Main Methods:
- Utilizing molecular carriers with high affinity for tumor cell antigens.
- Employing radionuclides for targeted delivery.
- Leveraging advancements in cancer biology, bioengineering, and radiochemistry.
Main Results:
- Targeted radionuclide therapy demonstrates reduced collateral damage compared to external beam therapy.
- Effective delivery to neoplastic malformations, including metastasized cells and clusters.
- Significant growth in therapeutic potential driven by interdisciplinary advancements.
Conclusions:
- Targeted radionuclide therapy is a promising systemic cancer treatment.
- Its efficacy is enhanced by molecular targeting and advancements in related sciences.
- The review covers progress in hematological malignancies and strategies for solid tumors.
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