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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Notch Signaling Pathway03:14

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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Canonical Wnt Signaling Pathway02:54

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Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Related Experiment Video

Updated: Mar 28, 2026

Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro
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Notch Signaling in Pancreatic Development.

Xu-Yan Li1,2, Wen-Jun Zhai3, Chun-Bo Teng4

  • 1College of Life Science, Northeast Forestry University, Harbin 150040, China. lxy0702@126.com.

International Journal of Molecular Sciences
|January 6, 2016
PubMed
Summary

The Notch signaling pathway is crucial for pancreas development, influencing progenitor cell differentiation. Its targeted inactivation promotes endocrine pancreas development, though its precise role remains debated.

Keywords:
Notch signalingdifferentiationmaintenancepancreatic progenitor

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Area of Science:

  • Developmental Biology
  • Endocrinology
  • Cell Signaling

Background:

  • Notch signaling is vital for embryonic cell fate and tissue homeostasis.
  • Notch signaling is extensively involved in pancreatic development, including progenitor differentiation and maintenance.
  • Inactivation of Notch pathway components accelerates endocrine pancreas differentiation.

Purpose of the Study:

  • To review current knowledge on Notch signaling in pancreatic development.
  • To explore the role of Notch signaling in pancreatic progenitor differentiation.
  • To examine the crosstalk between Notch, Wnt, and FGF pathways in pancreatic development.

Main Methods:

  • Literature review of studies on Notch signaling in pancreatic development.
  • Analysis of experimental data on Notch pathway inactivation in pancreatic models.
  • Examination of signaling pathway interactions using existing research.

Main Results:

  • Notch signaling plays a complex role in pancreatic progenitor differentiation.
  • Targeted Notch pathway inactivation leads to premature endocrine pancreas differentiation.
  • Contrasting views exist regarding Notch signaling's role in specifying endocrine lineage.

Conclusions:

  • Notch signaling is a key regulator in pancreatic development, with complex effects on endocrine differentiation.
  • Further research is needed to fully elucidate Notch signaling's precise role and its interactions with Wnt and FGF pathways.
  • Understanding these pathways is critical for regenerative medicine and treating pancreatic diseases.