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Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma
Evan F Garner1, Elizabeth A Beierle2
1Department of Surgery, Division of Pediatric Surgery, University of Alabama, Birmingham, AL 35233, USA. egarner@uabmc.edu.
Abstract:
Neuroblastoma, a solid tumor arising from neural crest cells, accounts for over 15% of all pediatric cancer deaths. The interaction of neuroblastoma cancer-initiating cells with their microenvironment likely plays an integral role in the maintenance of resistant disease and tumor relapse. In this review, we discuss the interaction between neuroblastoma cancer-initiating cells and the elements of the tumor microenvironment and how these interactions may provide novel therapeutic targets for this difficult to treat disease.
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