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Updated: Mar 28, 2026
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Synthesis of an In vivo MRI-detectable Apoptosis Probe
Published on: July 31, 2012
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Photo-click construction of a targetable and activatable two-photon probe imaging protease in apoptosis
Mi Zhou1, Jing Hu1, Mengmeng Zheng1
1State Key Laboratory of Analytical Chemistry for Life Science, Institute of Chemistry & BioMedical Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, P. R. China. njuzy@nju.edu.cn jinboli@nju.edu.cn.
Chemical Communications (Cambridge, England)
|January 6, 2016
Abstract:
A photo-click reaction was used as an efficient method to construct two-photon fluorescent probes bearing two functional peptides for targeting and for protease cleavage respectively. The activatable two-photon probe constructed by this method was applied to two-photon imaging of caspase-3 both in cellular apoptosis and in tumor tissue.
