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Protocol for the China PEACE (Patient-centered Evaluative Assessment of Cardiac Events) Million Persons Project pilot
Jiapeng Lu1, Si Xuan2, Nicholas S Downing3
1National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Insights
The China PEACE Million Persons Project pilot successfully demonstrated feasibility in collecting cardiovascular data from a large population. This initiative aims to improve precision medicine for cardiovascular disease (CVD) risk assessment and management in China.
Area of Science:
- Public Health
- Epidemiology
- Cardiovascular Medicine
Background:
- High-quality population data is crucial for precision medicine advancements.
- Cardiovascular disease (CVD) is a leading cause of mortality in China, necessitating improved risk assessment and modification strategies.
Purpose of the Study:
- To demonstrate the feasibility of a population-based assessment for cardiovascular risk in China.
- To collect comprehensive data for identifying factors to improve CVD risk assessment and management.
Main Methods:
- Pilot phase of the China Patient-centered Evaluative Assessment of Cardiac Events (PEACE) Million Persons Project.
- Screening of 0.4 million community-dwelling residents (aged 40-75) with measurements (BP, height, weight, lipids) and questionnaires.
- In-depth assessment, biobanking, lifestyle counseling, and follow-up for high-risk individuals.
Main Results:
- Preliminary analysis of the first 0.1 million participants provided baseline characteristics, health behaviors, anthropometrics, medical history, and high-risk prevalence.
- Demonstrated feasibility of large-scale population screening and data collection for cardiovascular health.
Conclusions:
- The pilot phase confirms the feasibility of the China PEACE Million Persons Project for large-scale cardiovascular data collection.
- Findings will inform strategies for precise CVD risk assessment and modification in the Chinese population.
Introduction:
Collection of high-quality data from large populations is considered essential to generate knowledge that is critical to an era of precision medicine. Cardiovascular disease (CVD) is a leading cause of mortality in China and is a suitable focus of an initiative to discover factors that would improve our ability to assess and modify individual risk.
Methods And Analysis:
The pilot phase of China PEACE (Patient-centered Evaluative Assessment of Cardiac Events) Million Persons Project is being conducted during 2014-2015 in four provinces across China to demonstrate the feasibility of a population-based assessment. It is designed to screen 0.4 million community-dwelling residents aged 40-75 years with measurements of blood pressure, height and weight, a lipid blood test, and a questionnaire on cardiovascular-related health status. Participants identified at high risk of CVD receive further health assessments, including ECG, ultrasound scan, blood and urine analysis, and a questionnaire on lifestyle and medical history. Collection of blood and urine samples is used to establish a biobank. High-risk subjects are also counselled with suggestions regarding potential lifestyle changes. In addition, high-risk subjects are followed-up either in a return clinic visit or by telephone interview, with measurement of blood pressure, weight, ECG, and a questionnaire on survival status, hospitalisations and lifestyle. The first 0.1 million participants screened were used to conduct a preliminary analysis, with information on baseline characteristics, health-related behaviours, anthropometric variables, medical history, and prevalence of high-risk subjects.
Ethics And Dissemination:
The central ethics committee at the China National Center for Cardiovascular Disease (NCCD) approved the pilot. Written informed consent is obtained from all participants on entry into the project. Findings will be disseminated in future peer-reviewed papers and will inform strategies aimed at developing precise methods of assessing and modifying risk.
Trial Registration Number:
NCT02536456.
