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Updated: Mar 28, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
Published on: February 22, 2018
Inflammatory markers and suicidal attempts in depressed patients: A review
Stefano Marini1, Federica Vellante2, Ilaria Matarazzo2
1Department of Neurosciences and Imaging, Chair of Psychiatry, University "G. D'Annunzio", Chieti, Italy sfnmarini@gmail.com.
Abstract:
Major depressive disorder is a chronic and invalidating psychiatric illness and is associated with a greater risk of suicidal behaviors. In recent decades many data have supported a biological link between depressive states and inflammation. Pro-inflammatory cytokines have been found to rise, first of all TNF-α and IL-6. Suicidal behaviors have been consistently associated with increased levels of IL-6 and decreased levels of IL-2. The aim of this review is to investigate the relationship between inflammatory markers in depressed patients with or without suicidal attempts compared to healthy controls.
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