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Related Experiment Videos

Isoimmunization in haemophiliacs.

C Louizou, C Panayotopoulou, A Antonopoulou

    Scandinavian Journal of Haematology. Supplementum
    |January 1, 1977
    PubMed
    Summary
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    Repeated blood transfusions in Greek hemophiliacs led to a 12.7% incidence of blood group antibodies, including anti-D in 35.3% of D-negative patients, highlighting transfusion complications.

    Area of Science:

    • Hematology
    • Immunology
    • Transfusion Medicine

    Background:

    • Hemophilia management often requires repeated transfusions of blood products.
    • Multitransfused patients are at risk for alloimmunization.
    • Previous studies have indicated varying rates of antibody formation in transfusion recipients.

    Purpose of the Study:

    • To investigate the incidence of blood group antibodies in Greek hemophiliacs.
    • To determine the specific types of antibodies formed, particularly anti-D.
    • To assess the implications of repeated plasma transfusions on immune sensitization.

    Main Methods:

    • Serum samples from 134 Greek hemophiliacs were analyzed.
    • Samples were tested against a panel of selected red blood cells with known genotypes.

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  • Standard serological methods were employed to detect blood group antibodies.

    • Main Results:

    • A 12.7% incidence of blood group antibodies was observed in the studied hemophiliacs.
    • Anti-D antibodies were identified in 6 of 17 (35.3%) D-negative, immunized patients.
    • This indicates significant sensitization following repeated transfusions.

    Conclusions:

    • Repeated plasma transfusions pose a significant risk of immune sensitization in hemophiliacs.
    • The high incidence of antibody formation, especially anti-D, is a serious complication.
    • Current transfusion practices may require re-evaluation to mitigate alloimmunization risks.