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Published on: December 1, 2017

Isoimmunization in haemophiliacs

C Louizou, C Panayotopoulou, A Antonopoulou

    Scandinavian Journal of Haematology. Supplementum
    |January 1, 1977
    PubMed

    Serum samples from 134 Greek haemophiliacs multitransfused with fresh frozen plasma and factor--VIII or factor--IX concentrates were investigated for the presence of blood group antibodies. All samples were tested against a panel of selected cells of known but differing genotype. The incidence of blood group antibodies was 12.7%. Anti-D was found in 6 out of the 17 immunized patients, i.e., 35.3% of D-negative haemophiliacs were sensitized. It is concluded that the high incidence of immunization is a serious complication of repeated plasma transfusions.

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