New therapies for arterial hypertension

Area of Science:

• Cardiology
• Pharmacology
• Nephrology

Background:

• Arterial hypertension is a prevalent chronic disease and a major risk factor for cardiovascular and renal diseases.
• Approximately 30-45% of the general population has hypertension.
• A significant percentage of hypertensive patients (15-20%) remain uncontrolled even with dual therapy.

Purpose of the Study:

• To review recent therapeutic advances in managing hypertension.
• To discuss novel drugs, devices, and procedures for hypertension and its comorbidities.
• To address the unmet need in treating refractory and resistant hypertension.

Main Methods:

• Comprehensive review of current literature on hypertension management.
• Analysis of recent advancements in both pharmacological and interventional treatments.
• Discussion of therapeutic strategies for high-risk hypertensive populations.

Main Results:

• Limited new antihypertensive drug classes have emerged recently.
• Long-term adherence to cardiovascular medications remains a challenge.
• Refractory and resistant hypertension represent a significant clinical challenge requiring novel approaches.

Conclusions:

• There is a critical need for new drugs, devices, and procedures to improve blood pressure control in high-risk patients.
• Advances in medical therapy and interventional procedures are essential for managing resistant hypertension.
• Addressing compliance issues and developing innovative treatments are key to improving outcomes for hypertensive patients.