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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Two-Dimensional, pH-Responsive Oligoglycine-Based Nanocarriers.

Rosa Garriga1, Izabela Jurewicz2, Elena Romero3

  • 1Departamento de Química Física, Universidad de Zaragoza , 50009 Zaragoza, Spain.

ACS Applied Materials & Interfaces
|January 6, 2016
PubMed
Summary

Atomically smooth peptide sheets, called tectomers, act as efficient nanocarriers. These biocompatible materials offer pH-controlled drug loading and release, showing promise for biosensing and therapeutics.

Keywords:
fluorescencenanocarriersoligoglycinepH-controlled releasetectomers

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Area of Science:

  • Supramolecular Chemistry
  • Materials Science
  • Nanotechnology

Background:

  • Two-dimensional (2D) materials offer unique properties for nanocarrier development.
  • Peptide-based self-assembly provides biocompatible platforms for drug delivery.
  • Controlled loading and release of therapeutic agents remain a challenge in nanomedicine.

Purpose of the Study:

  • To demonstrate the nanocarrier capabilities of atomically smooth 2D sheets of a biantennary oligoglycine peptide (tectomers).
  • To investigate the pH-controlled assembly and disassembly for drug loading and release.
  • To evaluate the loading capacity and stability of these peptide nanocarriers.

Main Methods:

  • Synthesis and characterization of biantennary oligoglycine peptide tectomers.
  • pH-controlled self-assembly and disassembly experiments.
  • Loading and release studies using the anticancer drug and fluorescent probe coralyne.
  • Partition coefficient calculations and photostability assessments.

Main Results:

  • Oligoglycine peptide tectomers exhibit efficient nanocarrier capabilities.
  • pH-controlled assembly/disassembly enables controlled loading and release of coralyne.
  • Tectomers show high loading capacity, comparable or superior to liposomes and micelles.
  • Loading within tectomers protects guest molecules from photochemically induced degradation.

Conclusions:

  • Oligoglycine peptide tectomers are efficient, pH-sensitive, stable, and biocompatible nanocarriers.
  • These nanocarriers are attractive for biosensing, therapeutic, and theranostic applications.
  • The planar self-assembled materials can also function as phase-transfer vehicles for hydrophobic cargoes.