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Related Concept Videos

Biological Causes of Schizophrenia01:29

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Related Experiment Video

Updated: Mar 27, 2026

Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells
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Dysfunction in the coagulation system and schizophrenia.

S Hoirisch-Clapauch1, O B Amaral2, M A U Mezzasalma3,4

  • 1Department of Hematology, Hospital Federal dos Servidores do Estado, Ministry of Health, Rio de Janeiro, Brazil.

Translational Psychiatry
|January 6, 2016
PubMed
Summary
This summary is machine-generated.

Schizophrenia may involve coagulation pathway abnormalities, specifically low tissue plasminogen activator (tPA) activity. Free-protein S deficiency and other conditions affecting tPA and protein S activity are prevalent in schizophrenia patients.

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Area of Science:

  • Neuroscience
  • Hematology
  • Psychiatry

Background:

  • Schizophrenia pathogenesis remains poorly understood, with weak links between existing hypotheses.
  • Warfarin therapy in psychotic patients led to the hypothesis of coagulation pathway involvement.
  • Low tissue plasminogen activator (tPA) activity is suspected as a missing link in schizophrenia.

Purpose of the Study:

  • To investigate the role of coagulation factors, specifically tPA and free-protein S, in schizophrenia.
  • To explore the association between conditions affecting tPA and protein S activity and schizophrenia phenotype.
  • To review the physiological roles of tPA and protein S in schizophrenia pathogenesis and comorbidity.

Main Methods:

  • Screening of schizophrenia patients and controls for conditions affecting tPA activity.
  • Assessment of free-protein S and protein C levels in participants.
  • Analysis of the prevalence of multiple conditions affecting tPA and/or protein S activity.

Main Results:

  • Free-protein S deficiency was highly prevalent in schizophrenia patients but absent in controls.
  • All participants had normal protein C levels, suggesting an independent role for protein S.
  • Schizophrenia patients exhibited multiple conditions affecting tPA and/or protein S activity, correlating with disease state.

Conclusions:

  • Abnormalities in the coagulation pathway, particularly involving tPA and free-protein S, are implicated in schizophrenia.
  • Multiple co-occurring conditions affecting tPA and protein S activity may contribute to the schizophrenia phenotype.
  • Future research should focus on animal models and therapeutic strategies targeting tPA and protein S activity.