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Updated: Mar 27, 2026
Real-time Analyses of Retinol Transport by the Membrane Receptor of Plasma Retinol Binding Protein
Published on: January 28, 2013
Serum Retinol-Binding Protein-4 Level is a High Risk Factor for Coronary Heart Disease in Chinese
Insights
Elevated serum retinol-binding protein-4 (RBP4) is a significant risk factor for coronary heart disease (CHD) and carotid artery plaque in Chinese populations. Early detection of RBP4 may aid in preventing and treating CHD.
Area of Science:
- Cardiovascular Research
- Biomarker Discovery
- Clinical Medicine
Background:
- Retinol-binding protein-4 (RBP4) is increasingly implicated in cardiovascular disease development.
- Understanding RBP4's role is crucial for identifying novel risk factors for cardiovascular conditions.
Purpose of the Study:
- To investigate the association between serum RBP4 levels and coronary heart disease (CHD) risk in a Chinese cohort.
- To determine if serum RBP4 is an independent risk factor for carotid artery plaque formation and CHD.
Main Methods:
- Enrolled 210 hospitalized cardiology patients (148 males, 62 females; average age 63.89 years).
- Classified patients into carotid plaque-free/plaque groups and no CHD/CHD groups.
- Measured serum RBP4 using ELISA and analyzed cardiovascular risk factors.
Main Results:
- Serum RBP4, hypertension, smoking, and age were independently linked to carotid artery plaque.
- Serum RBP4, hypertension, diabetes, and carotid artery plaque were independently associated with CHD.
- Elevated RBP4 levels showed a significant correlation with both conditions.
Conclusions:
- Elevated serum RBP4 is a key risk factor for carotid artery plaque and CHD in the Chinese population.
- Monitoring and managing serum RBP4 levels could be vital for CHD prevention and treatment.
- RBP4 serves as a potential biomarker for cardiovascular risk assessment.
Background:
Recent evidence suggests that retinol-binding protein-4 (RBP4) is involved in the pathogenesis of cardiovascular diseases. This study aimed to evaluate whether serum RBP4 level is a high risk factor for coronary heart disease (CHD) in Chinese.
Methods:
Two hundered ten consecutive patients hospitalized at the Department of Cardiology between September 2012 and September 2014 were enrolled, including 148 males and 62 females, with an average age 63.89 ± 13.05 years. The patients were divided into the carotid artery plaque-free group (130 cases) and carotid atherosclerosis plaque group (80 cases), or into the no CHD group (160 cases) and CHD group (50 cases). Data of cardiovascular risk factors were collected from each patient and analyzed. Serum RBP4 level was determined using an enzyme-linked immunosorbent assay. Results: The age, serum RBP4 level, smoking, and hypertension were independently associated with carotid artery plaque formation, while serum RBP4 level, hypertension, diabetes, and carotid artery plaque formation were independently associated with CHD.
Conclusions:
Elevated serum RBP4 level is one of the important risk factors for both carotid artery plaque formation and CHD in Chinese. Early detection and control of serum RBP level may help in the prevention, diagnosis, and therapy of CHD.
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