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Updated: Mar 27, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Electrocatalytic Generation of Amidyl Radicals for Olefin Hydroamidation: Use of Solvent Effects to Enable Anilide
Lin Zhu1, Peng Xiong1, Zhong-Yi Mao1
1Collaborative Innovation Center of Chemistry for Energy Material, Key Laboratory of Chemical Biology of Fujian Province, Department of Chemistry, Xiamen University, Xiamen, 361005, P. R. China.
Abstract:
Oxidative generation of synthetically important amidyl radicals from N-H amides is an appealing and yet challenging task. Previous methods require a stoichiometric amount of a strong oxidant and/or a costly noble-metal catalyst. We report herein the first electrocatalytic method that employs ferrocene (Fc), a cheap organometallic reagent, as the redox catalyst to produce amidyl radicals from N-aryl amides. Based on this radical-generating method, an efficient intramolecular olefin hydroamidation reaction has been developed.
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