Effect of functionalization on drug delivery potential of carbon nanotubes
Sonam Sharma1, Neelesh Kumar Mehra1, Keerti Jain1
1a Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences , I.S.F. College of Pharmacy , Moga , India.
Abstract:
The main aim of the present investigation was to explore the effect of functionalization on drug delivery potential of carbon nanotubes (CNTs) and to compare the in vitro and in vivo cancer targeting potential of doxorubicin HCL (DOX)-loaded ox-/multi-walled CNTs (MWCNTs), DOX-loaded PEG-MWCNTs and DOX-loaded FA-PEG-MWCNTs. The DOX/PEG-FA-MWCNTs showed enhanced cytotoxicity and were most preferentially taken up by the cancerous cells. The obtained results also support the extended resistance time and sustained release profile of drug-loaded surface-engineered MWCNTs. Overall, we concluded that the developed MWCNTs nanoformulations have higher cancer targeting potential.
Related Concept Videos
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Modified-Release Drug Delivery Systems: Site-Targeted
Factors Affecting Dissolution: Particle Size and Effective Surface Area


