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Updated: Mar 27, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Copper-catalyzed tandem Ullmann type C-N coupling and dehydrative cyclization: synthesis of
Nitesh K Nandwana1, Shiv Dhiman1, Ganesh M Shelke1
1Department of Chemistry, Birla Institute of Technology and Science, Pilani, 333031 Rajasthan, India. anilkumar@pilani.bits-pilani.ac.in.
Abstract:
A simple and efficient one-pot protocol has been demonstrated for the synthesis of imidazo[1,2-c]quinazoline derivatives through a copper catalyzed tandem reaction between substituted 2-(2-bromophenyl)-1H-imidazoles and formamide. The synthetic protocol involves initial Ullmann-type C-N coupling followed by intramolecular dehydrative cyclization. The method uses readily available 2-(2-bromophenyl)-1H-imidazoles as the starting materials to afford imidazo[1,2-c]quinazolines in moderate to good yields and provided 610 mg (71%) yield of 3a from a gram scale reaction.
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