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Updated: Mar 27, 2026

An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus
Published on: August 25, 2017
[Endemic kaposi's sarcoma in a HIV-Negative patient]
José Revilla-López1, Raúl Mendoza-Fabián2, Andrea Anampa-Guzmán2
1Hospital Nacional Daniel Alcides Carrión, Lima, Perú
Abstract:
Kaposi's sarcoma (KS) is a multicentric, inflammatory angioproliferative cancer associated with herpes virus 8 (HHV-8). It has four clinico-epidemiological types: classic, endemic, iatrogenic and epidemic, or HIV associated. Clinically it may be indolent or aggressive, mainly affecting mucocutaneous areas with eventual visceral and lymph node involvement. It is often present and in a more aggressive form in the HIV-positive population. We report a case of a 27-year-old HIV- negative male patient with a bleeding tumoral lesion in the Waldeyer ring, multiple lymphadenopathies and exophytic foot lesions that remit with anthracycline-based emergency chemotherapy. HIV-negative KS is a rare condition. It is important to consider Peru as an endemic region for HHV-8. The oral involvement of KS is a rare manifestation and of poor prognosis, however, the HIV-negative factor could confer a good prognosis.
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