Related Experiment Video
Updated: Mar 27, 2026

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
Published on: January 22, 2020
Vitamin D supplementation in neonates
1St Mary's Hospital, Imperial College NHS Trust.
Insights
Vitamin D deficiency affects many babies, but a simple leaflet intervention significantly improved correct supplementation uptake from 40% to 71%. This highlights the effectiveness of accessible information for infant vitamin D levels.
Area of Science:
- Pediatrics
- Public Health
- Nutritional Science
Background:
- Vitamin D deficiency is a significant concern in infants, potentially leading to rickets.
- Audits in a London hospital revealed low vitamin D levels in babies attending a prolonged jaundice clinic.
- Existing supplementation guidelines for General Practitioners (GPs) were lengthy and complex.
Purpose of the Study:
- To audit vitamin D levels in breastfed infants presenting with prolonged jaundice.
- To evaluate the effectiveness of a simplified leaflet intervention on vitamin D supplementation uptake.
- To improve adherence to recommended vitamin D supplementation protocols for infants.
Main Methods:
- An initial audit identified vitamin D deficient/insufficient breastfed infants in a prolonged jaundice clinic (August-December 2012).
- A simplified leaflet detailing vitamin D supplementation guidelines was created and distributed to mothers and their GPs.
- A re-audit assessed supplementation uptake in a new cohort of infants who received the leaflet (August-November 2013).
Main Results:
- The initial audit found 71% of infants had vitamin D deficiency.
- Prior to the intervention, only 40% of deficient infants received the correct vitamin D supplementation.
- Post-intervention, correct supplementation uptake increased significantly to 71%.
Conclusions:
- A simplified leaflet intervention is a highly effective method for improving vitamin D supplementation uptake in infants.
- Addressing vitamin D deficiency in infants requires accessible and clear guidance for both parents and healthcare providers.
- The leaflet intervention was successfully integrated into hospital trust guidelines due to its positive impact.
Abstract:
Vitamin D deficiency may lead to the development of rickets. In our paediatrics department in a major London hospital, we audited the number of babies with low vitamin D levels attending our prolonged jaundice clinic. Prior to our newly designed intervention, those babies with low vitamin D levels would be given a letter to encourage collection of supplementation from their GP. The GP would receive a letter which included a 14-page guideline on vitamin D supplementation. For this project, we included all breastfed babies that attended our prolonged jaundice clinic between August 2012 and December 2012. Those babies that were either vitamin D deficient or insufficient were identified. We then followed up these patients and asked them whether they were being prescribed the correct supplementation after being identified as vitamin deficient. For our intervention, we designed a leaflet to simplify guidelines that was then distributed to mothers and their GPs. Following this intervention, we re-audited the new cohort of patients who received the leaflet between August and November 2013. The study found 71% of babies to be vitamin D deficient. Moreover, almost two in five mothers had less than the recommended six months of vitamin supplementation during pregnancy. After identifying a deficiency, one would expect that uptake of vitamin supplementation would increase dramatically. However, only four in 10 babies went on to receive the correct dose and preparation of supplements. A marked increase in uptake was seen during the re-audit post intervention, with 71% of babies receiving correct supplementation. While an increase in government advertising would have contributed to the rise in uptake of vitamin D supplementation, a leaflet proved to be a simple yet effective intervention in improving vitamin uptake in babies. As a result, this was then implemented as part of trust guidelines.
Related Concept Videos
Role of Skin in Vitamin D Synthesis
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
Drug Dosing: Infants and Children
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Vitamins
Pharmacokinetics in Pediatric Patients: Drug Excretion
Pharmacokinetics in Pediatric Patients: Drug Distribution
