Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Redox Reactions01:24

Redox Reactions

59.4K
Oxidation-reduction or redox reactions involve the transfer of electrons from one molecule or atom to another. When an atom gains an electron, another atom must lose an electron, meaning oxidation and reduction must occur together. Since the redox occurs in pairs, the atom that gets oxidized is also called the reducing agent or reductant, and the atom that is reduced is also called the oxidizing agent or oxidant. A straightforward way to remember the definitions of oxidation and reduction is...
59.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Emission of Photons by Near-Infrared PbS Quantum Dot Nanocrystals for a Large Diameter Range.

The journal of physical chemistry. C, Nanomaterials and interfaces·2026
Same author

Polyurethane Depolymerization With Alkyl, Aryl, and Mixed Carbonates.

ChemSusChem·2026
Same author

Automated Generation of Supported Lipid Bilayer Arrays with Controlled Receptor Densities in Well Plates.

ACS applied materials & interfaces·2026
Same author

Material-Selective Deposition of Reactive Group-Functionalized Poly‑l‑lysine for DNA Sensing at Optical Waveguides.

ACS omega·2025
Same author

Quantifying and Controlling DNA Probe Density on the Surface of Silicon Nitride Optical Waveguides.

Langmuir : the ACS journal of surfaces and colloids·2025
Same author

Digital Detection of DNA via Impedimetric Tracking of Probe Nanoparticles.

Nano letters·2025

Related Experiment Video

Updated: Mar 27, 2026

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

2.0K

Size-controlled and redox-responsive supramolecular nanoparticles.

Raquel Mejia-Ariza1, Gavin A Kronig1, Jurriaan Huskens1

  • 1Molecular NanoFabrication group, MESA+ Institute for Nanotechnology University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.

Beilstein Journal of Organic Chemistry
|January 7, 2016
PubMed
Summary

Researchers developed stable supramolecular nanoparticles (SNPs) for drug delivery by balancing host-guest interactions and electrostatic forces. These nanoparticles can be reversibly assembled and disassembled, offering controlled drug delivery potential.

Keywords:
host–guest interactionsnanoparticlesself-assemblystimulus-responsivesupramolecular chemistry

More Related Videos

A 'Plug and Play' Method to Create Water-dispersible Nanoassemblies Containing an Amphiphilic Polymer, Organic Dyes and Upconverting Nanoparticles
12:51

A 'Plug and Play' Method to Create Water-dispersible Nanoassemblies Containing an Amphiphilic Polymer, Organic Dyes and Upconverting Nanoparticles

Published on: November 14, 2015

10.5K
Manganese Oxide Nanoparticle Synthesis by Thermal Decomposition of ManganeseII Acetylacetonate
09:02

Manganese Oxide Nanoparticle Synthesis by Thermal Decomposition of ManganeseII Acetylacetonate

Published on: June 18, 2020

14.0K

Related Experiment Videos

Last Updated: Mar 27, 2026

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

2.0K
A 'Plug and Play' Method to Create Water-dispersible Nanoassemblies Containing an Amphiphilic Polymer, Organic Dyes and Upconverting Nanoparticles
12:51

A 'Plug and Play' Method to Create Water-dispersible Nanoassemblies Containing an Amphiphilic Polymer, Organic Dyes and Upconverting Nanoparticles

Published on: November 14, 2015

10.5K
Manganese Oxide Nanoparticle Synthesis by Thermal Decomposition of ManganeseII Acetylacetonate
09:02

Manganese Oxide Nanoparticle Synthesis by Thermal Decomposition of ManganeseII Acetylacetonate

Published on: June 18, 2020

14.0K

Area of Science:

  • Materials Science
  • Nanotechnology
  • Supramolecular Chemistry

Background:

  • Controlling nanoparticle assembly and disassembly is crucial for effective drug delivery systems.
  • Supramolecular nanoparticles (SNPs) offer reversible assembly through host-guest interactions.
  • Stimulus-responsive moieties can enhance the functionality of nanoparticles.

Purpose of the Study:

  • To create supramolecular nanoparticles (SNPs) with controlled assembly and disassembly for potential drug delivery applications.
  • To investigate the influence of host-guest interactions, electrostatic forces, and ionic strength on SNP formation and stability.
  • To achieve stable SNPs with tunable size and reversible properties.

Main Methods:

  • Synthesized SNPs using a core of poly(ethylene imine) grafted with β-cyclodextrin (host) and a ferrocene-terminated dendrimer (guest).
  • Investigated the effect of ionic strength on aggregate growth and stability.
  • Utilized Job plot analysis to determine optimal host-guest stoichiometry (1:1).
  • Employed different stabilizers to control nanoparticle size and limit growth.

Main Results:

  • Ionic strength significantly impacts aggregate growth; higher ionic strength leads to faster growth due to reduced electrostatic repulsion.
  • A 1:1 stoichiometry of host (β-cyclodextrin) and guest (ferrocene) moieties promotes efficient aggregate growth.
  • Steric repulsion and the choice of stabilizer are critical for achieving SNP stability, with controlled sizes and stability up to seven days observed.
  • Reversibility was confirmed by oxidizing ferrocene moieties to ferrocenium cations, disrupting CD-Fc binding.

Conclusions:

  • Supramolecular nanoparticles with controlled size and stability were successfully prepared by balancing multivalent and monovalent interactions.
  • The developed SNPs demonstrate reversible assembly/disassembly triggered by oxidation of ferrocene, indicating potential for controlled drug release.
  • Fine-tuning electrostatic and steric interactions is key to designing stable and functional supramolecular nanostructures.