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Updated: Mar 27, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis, lipophilicity and antimicrobial activity evaluation of some new thiazolyl-oxadiazolines
Cristina Ioana Stoica1, Ioana IonuȚ2, Adrian Pîrnău3
1Therapeutical Chemistry Department, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Background And Aims:
Synthesis of new potential antimicrobial agents and evaluation of their lipophilicity.
Methods:
Ten new thiazolyl-oxadiazoline derivatives were synthesized and their structures were validated by 1H-NMR and mass spectrometry. The lipophilicity of the compounds was evaluated using the principal component analysis (PCA) method. The necessary data for applying this method were obtained by reverse-phase thin-layer chromatography (RP-TLC). The antimicrobial activities were tested in vitro against four bacterial strains and one fungal strain.
Results:
The lipophilicity varied with the structure but could not be correlated with the antimicrobial activity, since this was modest.
Conclusions:
We have synthesized ten new heterocyclic compounds. After their physical and chemical characterization, we determined their lipophilicity and screened their antimicrobial activity.
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