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Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

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The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
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Inflammation01:38

Inflammation

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Overview
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T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

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The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
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The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

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Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
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Related Experiment Video

Updated: Mar 27, 2026

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
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Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

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CXCL14 as an emerging immune and inflammatory modulator.

Jing Lu1, Mita Chatterjee1, Hannes Schmid1

  • 1Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Universität Tübingen, Otfried-Müller-Strasse 10, 72076 Tübingen, Germany.

Journal of Inflammation (London, England)
|January 7, 2016
PubMed
Summary

Chemokine CXCL14 (C-X-C motif chemokine ligand 14) regulates immune cell movement and antimicrobial immunity. Its receptor and signaling pathways require further investigation for a complete understanding of its functions.

Keywords:
Antimicrobial activityCXCL14InfectionInflammationMigration

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Related Experiment Videos

Last Updated: Mar 27, 2026

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Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment
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Area of Science:

  • Immunology
  • Molecular Biology
  • Biochemistry

Background:

  • CXCL14 is a novel chemokine with diverse biological activities.
  • It plays a role in immune cell migration and antimicrobial immunity.
  • The receptor and intracellular signaling pathways of CXCL14 are not fully understood.

Purpose of the Study:

  • To review the role of CXCL14 in immune cell migration and antimicrobial immunity.
  • To discuss the mechanisms regulating CXCL14 expression.
  • To explore potential CXCL14-mediated functional implications in various cells.

Main Methods:

  • Literature review of existing studies on CXCL14.
  • Analysis of biological mechanisms regulating CXCL14 expression.
  • Discussion of functional implications based on current research.

Main Results:

  • CXCL14 is involved in regulating immune cell migration.
  • CXCL14 contributes to antimicrobial immunity.
  • The precise receptor and downstream signaling of CXCL14 remain to be identified.

Conclusions:

  • CXCL14 has significant roles in immunity.
  • Further research is needed to elucidate its receptor and signaling pathways.
  • Understanding CXCL14 mechanisms can reveal new therapeutic targets.